People in the US are experiencing many mental and physical diseases, ailments, and chronic conditions that were not nearly as prominent in years past. Some experts believe there is a definite link between chemicals and the state of poor health in the US.

Metabolic Dysfunction Statistics: 93.2% of Americans have at least one marker of metabolic dysfunction according to a study published in the Journal of the American College of Cardiology. The study analyzed health data from over 55,000 Americans and found that only 6.8% were metabolically healthy. This alarming statistic highlights widespread issues like insulin resistance, high cholesterol, and high blood pressure, all linked to poor diet and lifestyle choices​. The study concluded that U.S. cardiometabolic health has been poor and worsening between 1999 and 2000 and 2017 and 2018, with only 6.8% of adults having optimal cardiometabolic health.

Processed Foods: Their concerns about the impact of ultra-processed foods are backed by extensive research in nutritional science. A 2019 study published in The BMJ found that higher consumption of ultra-processed foods was associated with an increased risk of all-cause mortality. Ultra-processed foods are often rich in refined sugars, unhealthy fats, and chemical additives, which have been linked to insulin resistance and chronic inflammation—key drivers of metabolic syndrome. The study concluded that “higher consumption of ultra-processed foods (>4 servings daily) was independently associated with a 62% relatively increased hazard for all-cause mortality. For each additional serving of ultra-processed food, all-cause mortality increased by 18%.”

Endocrine-Disrupting Chemicals (EDCs): The risks associated with chemicals like BPA and phthalates are well-documented. The Endocrine Review has published multiple position papers discussing how EDCs interfere with the body’s hormonal systems, contributing to obesity, diabetes, and reproductive health issues. The thyroid’s hormone signaling plays a critical role in metabolism, growth, and development. EDCs impact endocrine disruptors, from chemicals like bisphenol A (BPA), phthalates, and industrial pollutants like polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs). These substances, along with herbicides and pesticides like atrazine and DDT, can interfere with thyroid function, leading to various health issues.

Environmental Toxins: Heavy metals, pesticides, and airborne pollutants have been linked to numerous health issues, including mitochondrial dysfunction. A 2014 review in Environmental Research connected chronic exposure to environmental toxins like arsenic, lead, mercury, cadmium, chromium, aluminum, iron, and pesticides to metabolic diseases through their detrimental effects on mitochondrial function and oxidative stress. Failure to better manage the exposure of heavy metals will ultimately result in severe complications in the future, due to the adverse effects imposed by these elements and relative substances.

References:

Metabolic Dysfunction Statistics:

• O’Hearn, M., Lauren, B. N., Wong, J. B., Kim, D. D., & Mozaffarian, D. (2022). Trends and Disparities in Cardiometabolic Health among U.S. adults, 1999-2018. Journal of the American College of Cardiology, 80(2), 138–151. https://doi.org/10.1016/j.jacc.2022.04.046

Processed Foods:

• Rico-Campà, A., Martínez-González, M. A., Alvarez-Alvarez, I., De Deus Mendonça, R., De La Fuente-Arrillaga, C., Gómez-Donoso, C., & Bes-Rastrollo, M. (2019). Association between consumption of ultra-processed foods and all cause mortality: SUN prospective cohort study. BMJ, l1949. https://doi.org/10.1136/bmj.l1949

Endocrine-Disrupting Chemicals (EDCs):

• Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015). Executive summary to EDC-2: The Endocrine Society’s second Scientific Statement on Endocrine-Disrupting Chemicals. Endocrine Reviews, 36(6), 593–602. https://doi.org/10.1210/er.2015-1093
• Society, E. (2022, September 13). Ask the Expert: Endocrine Disrupting Chemicals (EDCs). Endocrine Society. https://www.endocrine.org/patient-engagement/hormone-headlines-blog/ate-heather-pautisal

Environmental Toxins:

• Jaishankar, M., Tseten, T., Anbalagan, N., Mathew, B. B., & Beeregowda, K. N. (2014). Toxicity, mechanism and health effects of some heavy metals. Interdisciplinary Toxicology, 7(2), 60–72. https://doi.org/10.2478/intox-2014-0009

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